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Tacrolimus API is isolated from streptomyces tsukubaensis. Tacrolimus is an immunosuppressive drug that is mainly used for allogeneic organ transplants to reduce the activity of the patients immune system and so lower the risk of organ rejection.
Tacrolimus ointment uses in topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplant, and the skin condition vitiligo and eczema. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide.
Product | Pharmacopeia | Therapeutic Segment |
Tacrolimus | IP/USP | Immunosuppressant |